Extramedullary Plasmacytoma Involving the Heart: A Case Report and Focused Literature Review

Cardiac tumors are extremely rare. Here, we report an unusual case of cardiac plasmacytoma that occurred 11 years after complete remission of the original multiple myeloma (MM). The tumor primarily manifested as a solitary extramedullary plasmacytoma (SEP) with extensive infiltration into the heart...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 12; no. 3; p. e7418
Main Authors Guan, Xuan, Jalil, Anum, Khanal, Kishor, Liu, Baoqiong, Jain, Akriti G
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 25.03.2020
Cureus
Subjects
Anemia
Blood clots
Bone marrow
Cardiology
Case reports
Chemotherapy
Dehydrogenases
Flow cytometry
Hematology
Hemoglobin
Immunoglobulins
Inhibitor drugs
Laboratories
Light
Medical imaging
Multiple myeloma
Oncology
Pathology
Peptides
Plasma
Proteins
Pulmonary arteries
Radiation therapy
Stem cells
Targeted cancer therapy
Tumors
Veins & arteries
magnetic resonance imaging
plasmacytoma
echocardiography
positron emission tomography-computed tomography
radiotherapy
computed tomography angiography
chemotherapy
heart
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Summary:Cardiac tumors are extremely rare. Here, we report an unusual case of cardiac plasmacytoma that occurred 11 years after complete remission of the original multiple myeloma (MM). The tumor primarily manifested as a solitary extramedullary plasmacytoma (SEP) with extensive infiltration into the heart and large vessels. There was no evidence of systemic involvement. The relapsing tumor assumed a unique immunophenotype from CD138+/CD38+/CD56- to CD138-/CD38+/CD56-. The patient responded to chemotherapy consisting of carfilzomib, cyclophosphamide, and dexamethasone. This case highlights the importance of multimodal imaging evaluation and tissue diagnosis for accurately characterizing this rare disorder.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7418