Benzimidazolin-2-ylidene N-heterocyclic carbene complexes of ruthenium as a simple catalyst for the N-alkylation of amines using alcohols and diols
Simple air and moisture stable ruthenium complexes 1–3 and 3a were synthesized from readily available benzannulated N -heterocyclic carbene ligands (bimy = benzimidazolin-2-ylidene). These complexes were found to be efficient catalysts for the alkylation of amines using alcohols as alkylating agents...
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Published in | RSC advances Vol. 5; no. 6; pp. 4434 - 4442 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Simple air and moisture stable ruthenium complexes
1–3
and
3a
were synthesized from readily available benzannulated
N
-heterocyclic carbene ligands (bimy = benzimidazolin-2-ylidene). These complexes were found to be efficient catalysts for the alkylation of amines using alcohols as alkylating agents. Catalysts
1
,
2
and
3a
gave excellent yields of up to 99% for the alkylation of various amines using benzylic and aliphatic alcohols at 130 °C for 18 h under solventless conditions. Catalyst
3a
bearing both phosphine and carbene ligands gave excellent yields of up to 98% for the synthesis of heterocyclic amines by double alkylation of primary amines using linear diols. The practical utility of these catalysts was demonstrated for the synthesis of pharmaceutically important amines in a more environmentally benign way under solventless conditions. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C4RA15398G |