A catalyst-free, one-pot multicomponent synthesis of spiro-benzimidazoquinazolinones via a Knoevenagel–Michael-imine pathway: a microwave assisted approach
A novel multi-component route for the synthesis of spiro-benzimidazoquinazolinones has been developed under microwave irradiation. It involves a one-pot three-component reaction of acenaphthoquinone or isatin, 1,3-diketone and 2-aminobenzimidazole in ethanol at 180 W and 160 °C temperature. An attra...
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Published in | RSC advances Vol. 6; no. 48; pp. 41897 - 41906 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2016
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Subjects | |
Online Access | Get full text |
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Summary: | A novel multi-component route for the synthesis of spiro-benzimidazoquinazolinones has been developed under microwave irradiation. It involves a one-pot three-component reaction of acenaphthoquinone or isatin, 1,3-diketone and 2-aminobenzimidazole in ethanol at 180 W and 160 °C temperature. An attractive feature of this method is the mild conditions with operational simplicity. The computational studies provide insight into the mechanistic aspects of the reaction. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C6RA05322J |