Relationship between coronary arterial remodeling and clinical presentation

• Published in: Chinese medical journal Vol. 116; no. 2; pp. 263 - 266
• Main Author: 杨震坤 沈卫峰 等
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Ruijin Hospital, Shanghai Second Medical University, S hanghai 200025, China 01.02.2003
• Subjects: Aged; Coronary Disease - diagnostic imaging; Coronary Disease - pathology; Coronary Disease - physiopathology; Coronary Vessels - physiopathology; Female; Humans; Male; Middle Aged; Ultrasonography; 临床表现; 冠状动脉改型; 冠状动脉疾病; 相关性; coronary artery disease; arteries; remodeling
• ISSN: 0366-6999; 2542-5641

Objective To examine the relationship between coronary arterial remodeling and clinical presentation.Methods A total of 34 patients with acute(10 with recent myocardial infarction and 24 with unstable angina)and 26 with stable(8 with old myocardial infarction and 18 with stable angina) coronary syndrome underwent intravascular ultrasound(IVUS)before intervention.Target lesions were classified as soft or hard plaques.Quantitative measurements of cross-sectional area(CSA)of external elastic membrance(EEM),lumen and plaque were performed at the lesion site and at the proximal and distal reference sites.Remodeling index(RI) was expressed by the ratio of EEM CSA at the lesion site to the mean EEM CSA of both proximal and distal reference sites.Positive remodeling was defined as RI>1.05 and negative remodeling as RI<0.95.Results Soft plaque was observed more frequently in acute than in stable coronary syndrome(59%,vs 31%),whereas hard plaque was more common in stable coronary syndrome(69% vs 41%)(P=0.03).The EEM CSA(15.11±2.89mm^2 vs 13.25±3.10mm^2,P=0.019)and plaque CSA(10.83±2.62mm^2 vs 9.30±2.84mm^2,P=0.035)were significantly greater at target lesions in patients with acute rather than stable coronary syndrome,while lumen CSA and percent area stenosis were similar in both groups.RI was significantly higher(1.08±0.16vs 0.95±0.14,P=0.002)and positive remodeling was more frequent in acute coronary syndrome(53%vs23%,P=0.019),whereas negative remodeling was more common in stable coronary syndrome(58% vs24%,P=0.007).Conclusions The study indicates that indicates that clinical characteristics of patients with coronary artery disease depend largely upon underlying types of coronary arterial remodeling.