Antimicrobial activity of non-natural prodigiosenes

Tripyrrolic prodigiosenes, derivatives of the natural product prodigiosin, have been produced viamulti-step synthesis beginning with 2-formyl pyrroles bearing various functionalities at the 4-position. Two tin complexes are also reported, and these feature a prodigiosene ligand bearing a conjugated...

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Published inRSC advances Vol. 3; no. 45; pp. 22967 - 22971
Main Authors Marchal, E., Uddin, Md. I., Smithen, D. A., Hawco, C. L. A., Lanteigne, M., Overy, D. P., Kerr, R. G., Thompson, A.
Format Journal Article
LanguageEnglish
Published 01.01.2013
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Summary:Tripyrrolic prodigiosenes, derivatives of the natural product prodigiosin, have been produced viamulti-step synthesis beginning with 2-formyl pyrroles bearing various functionalities at the 4-position. Two tin complexes are also reported, and these feature a prodigiosene ligand bearing a conjugated benzyl-ester. Antimicrobial activities of prodigiosenes are evaluated against Gram positive and Gram negative bacterial strains, as well as a yeast.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra45479g