Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

The work is directed toward the synthesis and characterization of gold nanoparticles coated by Gd-chelate (AudL), where L is a conjugate of diethylenetriamine-N,N,N',N",N"-pentaacetic acid (DTPA) and penicillamine. AudL is obtained by the replacement of citrate from Auitrate with gado...

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Published inJournal of materials chemistry Vol. 20; no. 26; pp. 5411 - 5417
Main Authors Kim, Hee-Kyung, Jung, Hee-Young, Park, Ji-Ae, Huh, Man-Il, Jung, Jae-Chang, Chang, Yongmin, Kim, Tae-Jeong
Format Journal Article
LanguageEnglish
Published 01.01.2010
Subjects
Blood
Conjugates
Contrast agents
Gold
Image contrast
Lymph
Pools
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Summary:The work is directed toward the synthesis and characterization of gold nanoparticles coated by Gd-chelate (AudL), where L is a conjugate of diethylenetriamine-N,N,N',N",N"-pentaacetic acid (DTPA) and penicillamine. AudL is obtained by the replacement of citrate from Auitrate with gadolinium chelate (GdL). The average size of AudL is 12 nm with the loading of GdL reaching up to 3.0 x 10 super(3) per particle, and they exhibit very high r sub(1) relaxivity (610 super(7) mM super(-1) s super(-1)) as well as X-ray attenuation. The r sub(1) relaxivity per [Gd] is 20.1 mM super(-1) s super(-1). The small size of the present system also exhibits a USPIO-like behavior, such as contrast enhancement in the liver, the blood pool and the lymph node, as demonstrated by histological and TEM images, as well as CT and MR, rendering itself as a new class of T sub(1) multimodal CT/MR contrast agent with potential application to the blood pool and the lymph node.
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ISSN:0959-9428
1364-5501
DOI:10.1039/c0jm00163e