Graphene oxide complex as a pH-sensitive antitumor drug

A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The res...

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Published inPolymer chemistry Vol. 6; no. 13; pp. 2401 - 2406
Main Authors Cheng, Rumei, Zou, Ruitao, Ou, Shengju, Guo, Rui, Yan, Ruiying, Shi, Haiyan, Yu, Shanshan, Li, Xiaojian, Bu, Yexu, Lin, Mimi, Liu, Yong, Dai, Liming
Format Journal Article
LanguageEnglish
Published 01.01.2015
Subjects
Drugs
Graphene
Human
Nanostructure
Oxides
Schiff bases
X-ray photoelectron spectroscopy
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Summary:A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.
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ISSN:1759-9954
1759-9962
DOI:10.1039/C5PY00047E