Synthesis of an analogue of the bisphosphonate drug Ibandronate for targeted drug-delivery therapeutic strategies

An analogue of the bisphosphonate drug Ibandronate was prepared and coupled via a cleavable ester function to a bromoacetyl linker with specific reactivity for thiol groups. This compound should find useful applications in therapeutic strategies aiming to deliver bisphosphonate drugs specifically to...

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Bibliographic Details
Published inNew journal of chemistry Vol. 34; no. 5; pp. 949 - 955
Main Authors Camper, Nicolas, Scott, Christopher J., Migaud, Marie E.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2010
Subjects
Bisphosphonates
Bone cancer
Cancer
Chemistry
Chemistry, Multidisciplinary
Cytotoxicity
Drugs
Esters
Ibandronic acid
Physical Sciences
Science & Technology
Therapeutic applications
Thiols
APOPTOSIS
CONVERSION
NITROGEN-CONTAINING BISPHOSPHONATES
ATP ANALOG
CONJUGATE
ALDEHYDES
BONE
MEVALONATE PATHWAY
PROTEINS
INHIBIT
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Summary:An analogue of the bisphosphonate drug Ibandronate was prepared and coupled via a cleavable ester function to a bromoacetyl linker with specific reactivity for thiol groups. This compound should find useful applications in therapeutic strategies aiming to deliver bisphosphonate drugs specifically to cancer cells making use of proteins as vectors. The specific delivery of bisphosphonates to cancer cells instead of bone, the usual site of accumulation of these cytotoxic drugs, could greatly widen their therapeutic applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1144-0546
1369-9261
DOI:10.1039/b9nj00597h