A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5 H -benzo[ e ][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purifica...

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Bibliographic Details
Published inRSC advances Vol. 5; no. 2; pp. 1268 - 1273
Main Authors Viviano, Monica, Milite, Ciro, Rescigno, Donatella, Castellano, Sabrina, Sbardella, Gianluca
Format Journal Article
LanguageEnglish
Published 01.01.2015
Subjects
Drugs
Libraries
Purification
Reduction
Scaffolds
Synthesis
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Summary:An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5 H -benzo[ e ][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purification steps and therefore could be conveniently used for the generation of compound libraries for drug discovery.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA13392G