Synthesis of [ 123 I]-iodometomidate from a polymer-supported precursor with a large excluded volume

We report on the synthesis of [ 123 I]-iodometomidate from a soluble polymer-supported precursor. The precursor was linked through a soluble polymer via a silyl linker polymer-supported precursor and released [ 123 I]-iodometomidate. The radiotracers were purified based on a combination of size-excl...

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Bibliographic Details
Published inRSC advances Vol. 6; no. 15; pp. 12215 - 12218
Main Authors Nakagawa, Chika, Toyama, Masahito, Takeuchi, Ryota, Takahashi, Takashi, Tanaka, Hiroshi
Format Journal Article
LanguageEnglish
Published 2016
Subjects
Chromatography
Precursors
Synthesis (chemistry)
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Summary:We report on the synthesis of [ 123 I]-iodometomidate from a soluble polymer-supported precursor. The precursor was linked through a soluble polymer via a silyl linker polymer-supported precursor and released [ 123 I]-iodometomidate. The radiotracers were purified based on a combination of size-exclusive and normal-phase chromatography to provide [ 123 I]-iodometomidate in good quality.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA00442C