Hypofractionated irradiation of the solid form of Ehrlich ascites carcinoma in mice by a thin scanning proton beam

• Published in: Biophysics (Oxford) Vol. 61; no. 4; pp. 682 - 686
• Main Authors: Balakin, V. E., Shemyakov, A. E., Zaichkina, S. I., Rozanova, O. M., Smirnova, E. N., Romanchenko, S. P., Sorokina, S. S., Strelnikova, N. S.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.07.2016; Springer Nature B.V
• Subjects: Beamforming; Biological and Medical Physics; Biophysics; Cancer; Complex Systems Biophysics; Physics; Physics and Astronomy; Protons; Radiation; Rodents; Scanning; Tumors; scanning pencil beam proton therapy; hypofractionation; mice; Ehrlich ascites carcinoma
• ISSN: 0006-3509; 1555-6654
• DOI: 10.1134/S0006350916040047

The dynamics of the growth of Ehrlich ascites carcinoma in mice of the SHK line exposed to hypofractionated high-dose irradiation by a thin scanning proton beam has been analyzed for different irradiation volumes and different time intervals (from 4 to 24 hours) between two 30-Gy fractions. Irradiation of the gross tumor volume and the planned target volume was performed within the Bragg peak; the energy of protons at the outlet of the accelerator ranged from 85 to 100 MeV. Hypofractionated irradiation of the gross tumor volume of Ehrlich ascites carcinoma resulted in a more pronounced antitumor effect than the irradiation of the planned target volume. The effect did not depend on the interval between the irradiation episodes.