RETRACTED: Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo through up-regulating miR-124

• Published in: Life sciences (1973) Vol. 216; pp. 147 - 155
• Main Authors: Gong, Gu, Gu, Yiqi, Zhang, Yunfeng, Liu, Wanguo, Li, Li, Li, Juan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2019
• Subjects: Abietanes - pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Apoptosis - drug effects; Autophagy - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Disease Models, Animal; Down-Regulation - drug effects; Flow Cytometry; Hydrogen Peroxide - toxicity; MAP Kinase Signaling System - drug effects; MicroRNAs - genetics; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases - metabolism; PC12 Cells; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - physiopathology; Up-Regulation - drug effects; miR-124; Oxidative stress; Tanshinone IIA; Spinal cord injury; JNK/p38 MAPK
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2018.11.046

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Corresponding Author with the agreement of the editor. The authors used DMSO (dimethyl sulfoxide) to dissolve tanshinone IIA in this experiment, but even after dilution, DMSO also can induce toxicity of PC12 cells, which also can affect the result of the experiment. After discussion, the authors found that sulfotanshinone sodium injection can be used to replace tanshinone II A, which is both an aqueous solution and has been clinically proved to be an ideal substitute. Further, in error, the authors used 0μM /12.5μM /50μM /100μM /200μM H2O2 to stimulate oxidative injury as in figure 1A, but missed 25μM H2O2, which may also affect the experimental results.