Surgical Treatment of Patients with Adenocarcinoma of the Distal Esophageal Portion and Gastroesophageal Junction Performed After Neoadjuvant Chemotherapy and Combined Chemoradiation

Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we present 3 patients with advanced moderately and low differentiated adenocarcinomas, who underwent neoadjuvant chemotherapy (nCT) (two patients) an...

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Published inActa Medica Bulgarica Vol. 49; no. 1; pp. 40 - 45
Main Authors Yankov, G., Alexieva, M., Kovacheva-Slavova, M., Vladimirov, B., Mekov, E.
Format Journal Article
LanguageEnglish
Published Sciendo 01.04.2022
Subjects
adenocarcinoma
esophageal carcinoma
esophagojejunoplasty
gastrectomy
gastroesophagoplasty
neoadjuvant therapy
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Summary:Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we present 3 patients with advanced moderately and low differentiated adenocarcinomas, who underwent neoadjuvant chemotherapy (nCT) (two patients) and combined nCT with neoadjuvant radiation therapy (nRT) (one patient), followed by radical surgery. Subtotal esophageal resection, proximal gastric resection, and intrathoracic right gastroesophagoplasty a modo Ivor-Lewis were performed in the first two patients, while total gastrectomy, distal third esophageal resection, splenectomy and left intrathoracic esophagojejunoplasty a modo Roux were performed in the third one. A literature review of the role of neoadjuvant chemoradiotherapy (nCRT) as part of a trimodality therapy for advanced esophageal carcinoma is presented.
ISSN:2719-5384
2719-5384
DOI:10.2478/amb-2022-0007