Results of a two year chronic toxicity study with hexachlorobutadiene in rats

Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms.

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Bibliographic Details
Published inAmerican Industrial Hygiene Association journal Vol. 38; no. 11; p. 589
Main Authors Kociba, R J, Keyes, D G, Jersey, G C, Ballard, J J, Dittenber, D A, Quast, J F, Wade, C E, Humiston, C G, Schwetz, B A
Format Journal Article
LanguageEnglish
Published United States 01.11.1977
Subjects
Adenocarcinoma - chemically induced
Adenoma - chemically induced
Animals
Body Weight - drug effects
Butadienes - administration & dosage
Butadienes - toxicity
Coproporphyrins - urine
Diet
Female
Kidney - drug effects
Kidney - pathology
Kidney Neoplasms - chemically induced
Kidney Tubules
Male
Neoplasms - etiology
Organ Size - drug effects
Rats
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Summary:Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms.
ISSN:0002-8894
DOI:10.1080/00028897708984403