When the Smoke Clears m6A from a Y Chromosome–Linked lncRNA, Men Get an Increased Risk of Cancer

Abstract Long noncoding RNAs (lncRNA) have been implicated in many diseases, including cancer. Although these disease-associated effects have been mostly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts, there is growing evidence that lncRNAs may also encode funct...

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Published inCancer research (Chicago, Ill.) Vol. 80; no. 13; pp. 2718 - 2719
Main Authors Banday, A. Rouf, Papenberg, Brenen W., Prokunina-Olsson, Ludmila
Format Journal Article
LanguageEnglish
Published 01.07.2020
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Summary:Abstract Long noncoding RNAs (lncRNA) have been implicated in many diseases, including cancer. Although these disease-associated effects have been mostly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts, there is growing evidence that lncRNAs may also encode functional micropeptides. In the current issue of Cancer Research, Wu and colleagues report a micropeptide encoded by a Y chromosome–linked lncRNA that may explain the higher incidence of esophageal cancer in male smokers. Furthermore, this report provides broader insights related to the molecular epidemiology of male-dominant and smoking-driven cancers and may also help explain some cancer-related associations with mosaic Y chromosome loss. See related article by Wu et al., p. 2790
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-20-0961