Influence of polyaniline on the potentiometric determination of risedronate with ion-selective membranes

A novel kind of potentiometric sensor for the determination of risedronate in pharmaceutical products is proposed. This potentiometric sensor is comprised of a poly(vinyl chloride) (PVC) membrane based on an anion-exchanger, tridodecylmethylammonium chloride (TDDMACl), and coated with a polyaniline...

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Published inAnalytical methods Vol. 2; no. 10; pp. 1614 - 1617
Main Authors Shishkanova, Tatiana V., Řezáčová (Zerzaňová), Anna, Král, Vladimir, Gospodinova, Natalia P.
Format Journal Article
LanguageEnglish
Published 01.10.2010
Subjects
Chlorides
Contaminants
Mathematical analysis
Membranes
Polyanilines
Polyvinyl chlorides
Potentiometric analysis
Sensors
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Summary:A novel kind of potentiometric sensor for the determination of risedronate in pharmaceutical products is proposed. This potentiometric sensor is comprised of a poly(vinyl chloride) (PVC) membrane based on an anion-exchanger, tridodecylmethylammonium chloride (TDDMACl), and coated with a polyaniline (PANI) layer. The potentiometric response towards a highly hydrated risedronate species was strongly promoted by the presence of the PANI layer. In contrast to uncoated membranes, the PANI-coated membrane exhibited a sensitivity of -39.9 +/- 0.9 mV decade-1 and the detection limit reached 0.45 mg mL-1. The results of the potentiometric analysis of risedronate agreed with those obtained with a validated chromatographic method. The TDDMACl-based membrane coated with the PANI layer differentiated 0.94 wt % and 3.44 wt % of a specific contaminant in 1.6 mg mL-1 risedronate.
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ISSN:1759-9660
1759-9679
DOI:10.1039/c0ay00382d