Econazole, a blocker of Ca2+ influx, selectively suppresses LTP of EPSPs in hippocampal slices

Econazole--an agent that suppresses Ca2+ influx triggered by depletion of internal Ca-stores in non-excitable cells--was bath-applied to submerged slices from Sprague-Dawley rats. Econazole (15-20 microM) had no consistent effect on afferent volleys, EPSPs or population spikes; but in seven out of n...

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Bibliographic Details
Published inNeuroscience letters Vol. 196; no. 1-2; pp. 122 - 124
Main Authors FORGHANI, R, KRNJEVIC, K
Format Journal Article
LanguageEnglish
Published Shannon Elsevier 18.08.1995
Subjects
Animals
Biological and medical sciences
Calcium Channel Blockers - pharmacology
Central nervous system
Econazole - pharmacology
Electrophysiology
Fundamental and applied biological sciences. Psychology
Hippocampus - drug effects
Long-Term Potentiation - drug effects
Male
Rats
Rats, Sprague-Dawley
Time Factors
Vertebrates: nervous system and sense organs
Potentiation
Vertebrata
Mammalia
Rat
Synaptic transmission
Rodentia
Calcium antagonist
Electrophysiology
Excitatory postsynaptic potential
Long term
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Summary:Econazole--an agent that suppresses Ca2+ influx triggered by depletion of internal Ca-stores in non-excitable cells--was bath-applied to submerged slices from Sprague-Dawley rats. Econazole (15-20 microM) had no consistent effect on afferent volleys, EPSPs or population spikes; but in seven out of nine slices, it prevented the induction of tetanic long-term potentiation (LTP) of field EPSPS. By contrast, all slices showed a marked LTP of population spikes. Ca2+ influx induced by tetanic depletion of Ca2+ stores may be essential for LTP of excitatory synaptic transmission.
Bibliography:ObjectType-Article-1
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ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(95)11838-N