Short Communication: Influence of Dietary Proteins on Production of Clostridium difficile Toxins in Gnotobiotic Mice

Inoculation of a toxigenic Clostridium difficile strain in axenic mice fed a commercial rodent diet led to pseudomembranous caecitis and death of animals within 2 d. Different diets derived from the commercial one were prepared, A 'Low protein diet' afforded 74 per cent protection. Several...

Full description

Saved in:
Bibliographic Details
Published inMicrobial ecology in health and disease Vol. 3; no. 4; pp. 231 - 234
Main Authors Dubos-ramaré, F., Corthier, G.
Format Journal Article
LanguageEnglish
Published Informa UK Ltd 1990
Taylor & Francis
Subjects
Clostridium difficile
Diet
Toxins
Online AccessGet full text

Cover

More Information
Summary:Inoculation of a toxigenic Clostridium difficile strain in axenic mice fed a commercial rodent diet led to pseudomembranous caecitis and death of animals within 2 d. Different diets derived from the commercial one were prepared, A 'Low protein diet' afforded 74 per cent protection. Several additives were given in the drinking water of mice fed the protective 'Low protein diet'. It was shown that some proteins and/or some small molecular weight compounds extracted from a brain-heart infusion prevented the protective effect provided by the 'Low protein diet'. Toxin production was reduced in all protected mice, while it was similar to the control in dead mice.
ISSN:0891-060X
1651-2235
1651-2235
DOI:10.3109/08910609009141547