Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

A cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the rea...

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Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 56; no. 3; pp. 418 - 426
Main Authors Petkovic, Milos, Kusljevic, Dusica, Jovanovic, Milos, Jovanovic, Predrag, Tasic, Gordana, Simic, Milena, Savic, Vladimir
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.02.2024
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HETEROCYCLIC SCAFFOLDS
cyclization reactions
allenes
AMINATION
piperizinones
combinatorial synthesis
NITROGEN-HETEROCYCLES
nucleophilic substitution
PIPERAZINONES
DRUGS
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Summary:A cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies.
ISSN:0039-7881
1437-210X
DOI:10.1055/a-2201-9951