Cutaneous vasculitis

Cutaneous vasculitides are inflammatory diseases starting at and evolving around the blood vessels of the skin. They should be separated from occluding vasculopathies, where the pathological process predominantely starts in the blood. They can be graded according to their relationship to systemic va...

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Published inDiagnostic histopathology (Oxford, England : 2008) Vol. 27; no. 1; pp. 6 - 12
Main Authors Ratzinger, Gudrun, Zelger, Bettina, Frischhut, Nina, Zelger, Bernhard
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2021
Subjects
cutaneous vasculitis
vasculitis
vasculopathy
vasculopathy
vasculitis
cutaneous vasculitis
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Summary:Cutaneous vasculitides are inflammatory diseases starting at and evolving around the blood vessels of the skin. They should be separated from occluding vasculopathies, where the pathological process predominantely starts in the blood. They can be graded according to their relationship to systemic vasculitides as a cutaneous component of a systemic vasculitis, as a skin-dominant variant of a systemic vasculitis or as a cutaneous single organ vasculitis. Diagnostic measures, therapy and prognoses depend greatly on this relationship. For diagnostic purposes, a classification based on histopathological features in asscociation with clinicopathological correlation seems most reliable. We differentiate according to vessel size (small-medium-large) and involved cell types (leukocytes, macrophages) as well as extravascular features (necroses, granulomas). Thus, the similarities and overlaps between different manifestations become apparent.
ISSN:1756-2317
1876-7621
DOI:10.1016/j.mpdhp.2020.10.009