The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats

• Published in: Journal of complementary & integrative medicine Vol. 12; no. 2; pp. 127 - 135
• Main Authors: Nasiri, Ebrahim, Hosseinimehr, Seyed Jalal, Azadbakht, Mohammad, Akbari, Jafar, Enayati-fard, Reza, Azizi, Sohail
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.06.2015
• Subjects: Animals; burn; Burns - drug therapy; Male; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; rat; Rats, Wistar; silver sulfadiazine; Silver Sulfadiazine - pharmacology; Silver Sulfadiazine - therapeutic use; Skin - drug effects; Skin - pathology; Terminalia; wound healing; Wound Healing - drug effects
• ISSN: 2194-6329; 1553-3840
• DOI: 10.1515/jcim-2014-0068

: The aim of this study was to evaluate the efficacy of ethanol extract of in the treatment of hot water-induced burn wounds and to compare the results with silver sulfadiazine (SSD) in rats. : Five groups of ten rats were burned with hot water. Animals were administrated with topical cream at control, normal saline, 5 %, 10 % extracts and standard SSD creams. Several parameters were assessed, including wound area, visual inspection of wound, bacteriology assessment, percentage of wound contraction and histopathological examination. : The average area of wound on 10th day was 11.2 ± 3.3, 11 ± 3.2, 8.5 ± 2.3, 9.5 ± 4.2 and 5.1 ± 2.2 cm for SSD1 %, base cream, normal saline, herbal extract 5 % and 10 %, respectively. 10 % cream exhibited lower wound size than SSD1 % and control groups at 10th day post burn injury. On day 15, the percentage of wound contraction in was 5 % and 10 % more than 18 % and 53 % in comparison to SSD1 % group, respectively. Histopathological results exhibited well-formed horizontally oriented collagen fibers for appropriate tension. Strength of scar on burned tissue was better in 5 % and 10 % as compared with control and SSD groups. : The results of this study showed that extract was capable of accelerating wound healing in rats by wound contraction, and had beneficial effects more than SSD 1 % cream in the management of burn injury.