Regionalized expression of the Dbx family homeo☐ genes in the embryonic CNS of the mouse
Here we report the identification of a novel homeo☐ gene family Dbx in mouse, which consists of Dbx and Dbx2. The two genes share similar structural organization and are encoded by different chromosomes. The predicted Dbx and Dbx2 proteins share 85% identity in their homeodomain amino acid sequences...
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Published in | Mechanisms of development Vol. 56; no. 1; pp. 25 - 39 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ireland Ltd
01.05.1996
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Subjects | |
Online Access | Get full text |
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Summary: | Here we report the identification of a novel homeo☐ gene family
Dbx in mouse, which consists of
Dbx and
Dbx2. The two genes share similar structural organization and are encoded by different chromosomes. The predicted
Dbx and
Dbx2 proteins share 85% identity in their homeodomain amino acid sequences, but otherwise showed no significant similarity. Characterization of the expression of these two genes in the embryos suggested their role in the development of the CNS. In the forebrain,
Dbx is expressed in various regions, while
Dbx2 showed a more restricted pattern of expression. In the midbrain, the expression domains of
Dbx and
Dbx2 overlap along the dorso-lateral wall of the ventricle. In the hindbrain and spinal cord, both genes are expressed in the boundary separating the basal and alar plates, which seems to correspond to the sulcus limitans. Expression of the Dbx/Dbx2 genes is restricted to the ventricular region of the embryonic CNS except for that of
Dbx in the septum of the telencephalon. Together these observations indicate possible participation of the members of the
Dbx family in regionalization of the CNS. While the expression of
Dbx was restricted to the CNS,
Dbx2 was also expressed in some of the mesenchymal cells, such as limb buds and tooth germs. |
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ISSN: | 0925-4773 1872-6356 |
DOI: | 10.1016/0925-4773(96)00509-6 |