The relationship between different dosages of mannitol 20% and osmolarity, blood sugar serum, and coagulation factors in moderate brain injury patients with increased intracranial pressure

• Published in: Medicina Clínica Práctica Vol. 4; p. 100235
• Main Authors: Wardoyo, Martin Saputro, Widodo, Djoko, Ihwan, Andi, Prihantono, Kusuma, Muhammad Ihwan, Hendarto, Joko, Adhimarta, Willy, Nasrullah, Faruk, Muhammad, Islam, Andi Asadul
• Format: Journal Article
• Language: English
• Published: Elsevier España, S.L.U 01.04.2021
• Subjects: Blood osmolarity; Coagulation factor; Intracranial pressure; Mannitol; Moderate brain injury; Serum blood sugar; Moderate brain injury; Intracranial pressure; Serum blood sugar; Coagulation factor; Mannitol; Blood osmolarity
• ISSN: 2603-9249; 2603-9249
• DOI: 10.1016/j.mcpsp.2021.100235

Traumatic brain injuries have high mortality rates in many countries. Chemical parameters such as blood osmolarity, serum blood sugar, and coagulation factors can be used to assess the prognosis of a brain injury. Increased intracranial pressure and swelling of the brain are clinical manifestations of brain injury. One option for non-operative treatment is the use of mannitol (MT). This research aims to determine the dosage of MT 20% that demonstrates better levels of safety and effectiveness, based on the evaluation of 3 laboratory-test parameters. This research is a prospective cohort with a total sample of 30 patients with moderate brain injuries, who are divided randomly into two groups of different dosages of MT. The results are analyzed using repeated measures ANOVA tests and are significant if p<0.05. We found differences in blood osmolarity, serum blood sugar, and coagulation factors between the two groups. A dosage of MT 20% 1g/kgBW has a higher value than a dosage of 0.5g/kgBW, but all were nonsignificant (p>0.05). MT 20% does not affect blood osmolarity, serum blood sugar, and coagulation factors.