Influences of ovariectomy and continuous replacement of 17beta-estradiol on the tail skin temperature and behavior in the forced swimming test in rats

The effect of ovariectomy and continuous subcutaneous replacement of 17beta-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17beta-Estrad...

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Published inJapanese journal of pharmacology Vol. 73; no. 1; pp. 93 - 96
Main Authors Okada, M, Hayashi, N, Kometani, M, Nakao, K, Inukai, T
Format Journal Article
LanguageEnglish
Published Japan 01.01.1997
Subjects
Animals
Antidepressive Agents, Tricyclic - pharmacology
Estradiol - pharmacology
Estradiol - therapeutic use
Estrogen Replacement Therapy
Female
Maprotiline - pharmacology
Motor Activity - drug effects
Ovariectomy
Rats
Rats, Wistar
Skin Temperature - drug effects
Tail - drug effects
Tail - physiology
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Summary:The effect of ovariectomy and continuous subcutaneous replacement of 17beta-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17beta-Estradiol at doses of 0.3 and 1.0 microg/body/day suppressed the increases in tail skin temperature. In the forced swimming test, the ovariectomized control rats showed significantly prolonged immobility time in comparison with sham-ovariectomized rats 14 days after ovariectomy. The duration of immobility of ovariectomized rats treated with 17beta-estradiol (0.3, 1.0, 3.0 microg/body/day) or maprotiline (0.6 mg/body/day) was significantly shorter than that of ovariectomized control rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.73.93