Modeling Vascular Aging Using Arterial Simulator

This study investigated the effects of vascular elastic modulus on hemodynamic characteristics using an arterial simulator. The simulator comprises a pulse generator that functions as a heart and an arterial system made of silicon. The arterial system was simplified to include only the body’s large...

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Bibliographic Details
Published inJournal of the Korean Physical Society Vol. 76; no. 4; pp. 341 - 347
Main Authors Jang, Min, Lee, Min-Woo, Lee, Jung-Hoon, Shin, Sang-Hoon
Format Journal Article
LanguageEnglish
Published Seoul The Korean Physical Society 01.02.2020
Springer Nature B.V
한국물리학회
Subjects
Arteries
Blood vessels
Computer simulation
Hemodynamics
Input impedance
Mathematical and Computational Physics
Modulus of elasticity
Particle and Nuclear Physics
Physics
Physics and Astronomy
Pulse generators
Silicon
Theoretical
물리학
Elastic modulus
Arterial aging
Arterial simulator
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Summary:This study investigated the effects of vascular elastic modulus on hemodynamic characteristics using an arterial simulator. The simulator comprises a pulse generator that functions as a heart and an arterial system made of silicon. The arterial system was simplified to include only the body’s large arteries and was manually constructed using silicon to emulate the elastic modulus of the body. Three arterial models (Young, Middle, and Old model) with the same geometrical characteristics but different distribution of elastic modulus were produced. And the hemodynamic effects of each arterial model were observed. Pulse wave velocity, pulse pressure, and input impedance were used as the evaluation indices. Additionally, the results of the simulator and clinical data were compared. As the elastic modulus of the vessel wall increased with age, the pulse wave velocity and pulse pressure exhibited a nonlinear increase. Studying the input impedance revealed the effects of increasing vascular resistance and reducing arterial compliance. Lastly, the performance of the simulator showed good agreement with clinical data of hemodynamic changes due to aging.
ISSN:0374-4884
1976-8524
DOI:10.3938/jkps.76.341