MiR-126 regulated myocardial autophagy on myocardial infarction

• Published in: European review for medical and pharmacological sciences Vol. 24; no. 12; p. 6971
• Main Authors: Shi, C-C, Pan, L-Y, Peng, Z-Y, Li, J-G
• Format: Journal Article
• Language: English
• Published: Italy 01.06.2020
• Subjects: Animals; Autophagy; Cells, Cultured; MicroRNAs - metabolism; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Rats; Rats, Sprague-Dawley
• ISSN: 2284-0729
• DOI: 10.26355/eurrev_202006_21689

The aim of the study is to detect the effect of miR-126 in autophagy after acute myocardial infarction (AMI). First, the changes of miR-126 and autophagy in myocardial infarction tissue and normal heart tissue were compared by establishing the myocardial infarction rat model, so as to clarify the relationship between miR-126 and changes of myocardial infarction and autophagy. Second, the regulation of miR-126 on autophagy related protein Beclin-1 and the role in myocardial infarction were studied to clarify whether miR-126 regulates autophagy through Beclin-1 and participates in the occurrence and development of myocardial infarction. Finally, the relationship between plasma miR-126 was observed. MiR-126 expression can regulate Beclin-1 expression and influence the cardiac function after AMI. The results are of great significance to reveal the new mechanism of myocardial infarction. The down-regulation of miR-126 will lead to the over-activation of myocardial autophagy induced by Beclin-1, which is an autophagy related protein. The plasm expression of miR-126 may be a clinical marker of autophagy after AMI.