Changes in the Kinetics of Evoked Secretion of Transmitter Quanta – an Effective Mechanism Modulating the Synaptic Transmission of Excitation

The main presynaptic mechanisms of synaptic plasticity are generally believed to consist of changes in the numbers of neurotransmitter quanta released in response to a nerve spike (the quantum composition of postsynaptic responses) and quantum size. However, studies in recent years have demonstrated...

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Bibliographic Details
Published inNeuroscience and behavioral physiology Vol. 42; no. 2; pp. 153 - 160
Main Authors Bukharaeva, E. A., Nikolskii, E. E.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.02.2012
Springer Nature B.V
Subjects
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Data processing
Nervous system
Neurobiology
Neurosciences
Physiology
Transmitters
Russia
neuromuscular junction
quantum release of acetylcholine
kinetics of evoked release of quanta
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Summary:The main presynaptic mechanisms of synaptic plasticity are generally believed to consist of changes in the numbers of neurotransmitter quanta released in response to a nerve spike (the quantum composition of postsynaptic responses) and quantum size. However, studies in recent years have demonstrated the existence of a further, previously unconsidered but effective mechanism modulating the synaptic transmission of excitation, which is associated with changes in the secretion time course (kinetics) of the release of the individual quanta forming the multiquantum postsynaptic response. This review discusses current data (including our own results) on the kinetics of the evoked release of neurotransmitter quanta from motor nerve endings in peripheral synapses, the mechanisms of its modulation, and quantitative methods for its analysis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-011-9548-9