Induction of macrophage-mediated hepatocytotoxicity by culture supernatant from LPS-activated Kupffer cells
Since the macrophage activation judging from the increased uptake of 3H-glucosamine into cells was observed by treatment of macrophage with culture supernatant from LPS-activated Kupffer cells, LPS-stimulated Kupffer cells were appeared to produce some substance caused the activated of macrophages a...
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| Published in | Kanzo Vol. 26; no. 7; pp. 877 - 882 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
1985
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.26.877 |
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| Abstract | Since the macrophage activation judging from the increased uptake of 3H-glucosamine into cells was observed by treatment of macrophage with culture supernatant from LPS-activated Kupffer cells, LPS-stimulated Kupffer cells were appeared to produce some substance caused the activated of macrophages and activated macrophages exhibited their hepatotoxic actions through the secretion of cytotoxic substance or direct contacts to target cells. |
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| AbstractList | Since the macrophage activation judging from the increased uptake of 3H-glucosamine into cells was observed by treatment of macrophage with culture supernatant from LPS-activated Kupffer cells, LPS-stimulated Kupffer cells were appeared to produce some substance caused the activated of macrophages and activated macrophages exhibited their hepatotoxic actions through the secretion of cytotoxic substance or direct contacts to target cells. |
| Author | YAMAMOTO, Sukeo MIYAJIMA, Keiji SEKI, Shunichi ARAI, Takayuki MORISAWA, Seiji KATOH, Hiroko TSUTSUI, Hiroko MIZOGUCHI, Yasuhiro |
| Author_xml | – sequence: 1 fullname: MIZOGUCHI, Yasuhiro organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: ARAI, Takayuki organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: MORISAWA, Seiji organization: The First Department of Biochemistry, Osaka City University Medical School – sequence: 1 fullname: YAMAMOTO, Sukeo organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: SEKI, Shunichi organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: TSUTSUI, Hiroko organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: KATOH, Hiroko organization: The Third Department of Internal Medicine, Osaka City University Medical School – sequence: 1 fullname: MIYAJIMA, Keiji organization: The Third Department of Internal Medicine, Osaka City University Medical School |
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| References | 5) Nadler PI, Klingenstein RJ, Richman LK: The murine Kupffer cell. II .Accessory cell function in in vitro primary antibody responses, mitogen-induced proliferation, and stimulation of mixed lymphocyte responses. J Immunol 125: 2521-2525, 1980 8) 新井孝之,溝口靖紘,加藤寛子,他:末梢血単核細胞のmitogenによる活性化に及ぼすKupffer細胞の影響.肝臓25: 1546-1551, 1984 9) Munthe-Kass AC, Berg T, Seglen PO: Mass isolation and culture of rat Kupffer cells. J Exp Med 141: 1-10, 1975 2) Mizoguchi Y, Shiba T, Ohnishi F: Possible involvement of macrophage-mediated hepatocytotoxicity in chronic active hepatitis: The induction of liver cell injury by culture supernatant of MAF-activated macrophages. Hepato-gastroenterol 28: 254-257, 1981 1) Mizoguchi Y, Shiba T, Ohnishi F: Immunological studies on chronic active hepatitis: Possible involvement of macrophagemediated cytotoxicity in its immunopathogenesis. Hepato-gastroenterol 28: 250-253, 1981 4) Richman LK, Klingenstein RJ, Richman JA: The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen specific T cell proliferation. J. Immunol 123: 2602-2609, 1979 6) 新井孝之,溝口靖紘,池本吉博,他:Kupffer細胞の免疫応答に及ぼす影響.日消誌81: 1781-1787, 1984 7) 溝口靖紘,加藤寛子,筒井ひろ子,他:Kupffer cellのantibody-dependent cell-mediated hepatocytotoxicityへの影響.肝臓25: 1552-1556, 1984 10) Bellemam P, Gebhardt R, Mecke D: An improved method for the isolated of hepatocytes from liver slice. Selective removed of trypanblue dyeable cells. Analytical Biochem 81: 408 3) Inchley CJ: The activity of mous Kupffer cells following intravenous injection of T4 bacteriophage. Clin Exp Immunol 5: 173-187, 1969 |
| References_xml | – reference: 5) Nadler PI, Klingenstein RJ, Richman LK: The murine Kupffer cell. II .Accessory cell function in in vitro primary antibody responses, mitogen-induced proliferation, and stimulation of mixed lymphocyte responses. J Immunol 125: 2521-2525, 1980 – reference: 10) Bellemam P, Gebhardt R, Mecke D: An improved method for the isolated of hepatocytes from liver slice. Selective removed of trypanblue dyeable cells. Analytical Biochem 81: 408 – reference: 1) Mizoguchi Y, Shiba T, Ohnishi F: Immunological studies on chronic active hepatitis: Possible involvement of macrophagemediated cytotoxicity in its immunopathogenesis. Hepato-gastroenterol 28: 250-253, 1981 – reference: 3) Inchley CJ: The activity of mous Kupffer cells following intravenous injection of T4 bacteriophage. Clin Exp Immunol 5: 173-187, 1969 – reference: 4) Richman LK, Klingenstein RJ, Richman JA: The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen specific T cell proliferation. J. Immunol 123: 2602-2609, 1979 – reference: 8) 新井孝之,溝口靖紘,加藤寛子,他:末梢血単核細胞のmitogenによる活性化に及ぼすKupffer細胞の影響.肝臓25: 1546-1551, 1984 – reference: 2) Mizoguchi Y, Shiba T, Ohnishi F: Possible involvement of macrophage-mediated hepatocytotoxicity in chronic active hepatitis: The induction of liver cell injury by culture supernatant of MAF-activated macrophages. Hepato-gastroenterol 28: 254-257, 1981 – reference: 6) 新井孝之,溝口靖紘,池本吉博,他:Kupffer細胞の免疫応答に及ぼす影響.日消誌81: 1781-1787, 1984 – reference: 7) 溝口靖紘,加藤寛子,筒井ひろ子,他:Kupffer cellのantibody-dependent cell-mediated hepatocytotoxicityへの影響.肝臓25: 1552-1556, 1984 – reference: 9) Munthe-Kass AC, Berg T, Seglen PO: Mass isolation and culture of rat Kupffer cells. J Exp Med 141: 1-10, 1975 |
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| Title | Induction of macrophage-mediated hepatocytotoxicity by culture supernatant from LPS-activated Kupffer cells |
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