Induction of macrophage-mediated hepatocytotoxicity by culture supernatant from LPS-activated Kupffer cells

Since the macrophage activation judging from the increased uptake of 3H-glucosamine into cells was observed by treatment of macrophage with culture supernatant from LPS-activated Kupffer cells, LPS-stimulated Kupffer cells were appeared to produce some substance caused the activated of macrophages a...

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Bibliographic Details
Published inKanzo Vol. 26; no. 7; pp. 877 - 882
Main Authors MIZOGUCHI, Yasuhiro, ARAI, Takayuki, MORISAWA, Seiji, YAMAMOTO, Sukeo, SEKI, Shunichi, TSUTSUI, Hiroko, KATOH, Hiroko, MIYAJIMA, Keiji
Format Journal Article
LanguageJapanese
Published The Japan Society of Hepatology 1985
Subjects
macrophage-mediated cytotoxicity
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ISSN0451-4203
1881-3593
DOI10.2957/kanzo.26.877

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Summary:Since the macrophage activation judging from the increased uptake of 3H-glucosamine into cells was observed by treatment of macrophage with culture supernatant from LPS-activated Kupffer cells, LPS-stimulated Kupffer cells were appeared to produce some substance caused the activated of macrophages and activated macrophages exhibited their hepatotoxic actions through the secretion of cytotoxic substance or direct contacts to target cells.
ISSN:0451-4203
1881-3593
DOI:10.2957/kanzo.26.877