Acute normovolaemic haemodilution does not reduce the inflammatory process induced by facial surgery

• Published in: Canadian journal of anesthesia Vol. 42; no. 4; pp. 305 - 309
• Main Authors: PEILLON, D, DUBOST, J, BIENVENU, J, CARRY, P. Y, ROCHE, C, BRETON, P, FREIDEL, M, BANSSILLON, V
• Format: Journal Article
• Language: English
• Published: Toronto, ON Canadian Anesthesiologists' Society 01.04.1995
• Subjects: Acute-Phase Proteins - analysis; Adolescent; Adult; Biological and medical sciences; Blood Volume; C-Reactive Protein - analysis; Edema - blood; Edema - prevention & control; Face - diagnostic imaging; Face - surgery; Female; Fibrinogen - analysis; Haptoglobins - analysis; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Hematocrit; Hemodilution - methods; Humans; Male; Mandible - surgery; Maxillofacial surgery. Dental surgery. Orthodontics; Medical sciences; Middle Aged; Orosomucoid - analysis; Osteotomy - adverse effects; Postoperative Complications - blood; Postoperative Complications - prevention & control; Prospective Studies; Radiography; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Telemetry; Human; Induced hemodilution; Edema; Osteotomy; Surgery; Complication; Dysmorphic facies; Inflammation; Preoperative; Face; Normovolemia
• ISSN: 0832-610X; 1496-8975
• DOI: 10.1007/BF03010707

The place of preoperative acute normovolaemic haemodilution (haematocrit = 28%-32%) in reducing postoperative inflammation was evaluated after facial surgery. Thirty-two patients scheduled for mandibular osteotomy were randomized to a nonhaemodiluted group or to a haemodiluted group. The degree of postoperative inflammation was evaluated: first by an x-ray technique (radiotelemetry) providing measurements of the tissue thickness (quantitation of facial oedema), and second by the measurement of four acute phase protein plasma concentrations during the first postoperative week. Throughout the study, no changes in facial oedema or in variation of acute phase proteins were detected after haemodilution. It is concluded that acute normovolaemic haemodilution has no effect on the intensity of facial oedema and the biological inflammation process after facial surgery.