CD103 fate mapping reveals that intestinal CD103 - tissue-resident memory T cells are the primary responders to secondary infection
Tissue-resident memory T (T ) cells remain poised in the tissue and mediate robust protection from secondary infection. T cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T subsets to secondary infection remain poorly...
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Published in | Science immunology Vol. 7; no. 77; p. eabl9925 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
11.11.2022
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Subjects | |
Online Access | Get more information |
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Summary: | Tissue-resident memory T (T
) cells remain poised in the tissue and mediate robust protection from secondary infection. T
cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T
subsets to secondary infection remain poorly defined. To address the plasticity of intestinal T
subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103
T
cells and track their location and function during secondary infection with
. We found that CD103
T
cells remained lodged in the tissue and were poorly reactivated during secondary challenge. CD103
T
cells were the primary responders to secondary infection and expanded within the tissue, with limited contribution from circulating memory T cells. The transcriptional profile of CD103
T
cells demonstrated maintenance of a gene signature similar to circulating T cells along with increased cytokine production and migratory potential. CD103
T
cells also expressed genes associated with T cell receptor (TCR) activation and displayed enhanced TCR-mediated reactivation both in vitro and in vivo compared with their CD103
counterparts. These studies reveal the limited recall potential of CD103
T
subsets and the role of CD103
T
cells as central memory-like T cells within peripheral tissues. |
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ISSN: | 2470-9468 |
DOI: | 10.1126/sciimmunol.abl9925 |