The influence of adenosine receptor ligands and hypoxic preconditioning on the metabolism of the brain tissue in the experiment

To study the influence of adenosine receptor ligands and hypoxic preconditioning on carbohydrate metabolism in global brain ischemia. The study included 51 outbred white male mice weighing 20-25 g. An effect of adenosine receptor ligands and hypoxic preconditioning on brain tissue metabolism, heat e...

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Bibliographic Details
Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 118; no. 7; p. 54
Main Authors Minakina, L N, Goldapel, E G, Usov, L A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2018
Subjects
Adenosine
Animals
Brain
Hypoxia
Ischemic Preconditioning
Ligands
Male
Mice
Receptors, Purinergic P1
brain metabolism
neuroprotection
adenosine receptors
longevity
body temperature
lactate/pyruvate ratio
ischemia
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Summary:To study the influence of adenosine receptor ligands and hypoxic preconditioning on carbohydrate metabolism in global brain ischemia. The study included 51 outbred white male mice weighing 20-25 g. An effect of adenosine receptor ligands and hypoxic preconditioning on brain tissue metabolism, heat exchange and longevity was explored. Adenosine, an agonist of A1 adenosine receptors, and hypoxic preconditioning exert a neuroprotective effect on brain cells. The blocker of A1 adenosine receptors aggravates metabolic disturbances in the brain and removes the protective effect of cyclopenyladenosine and ischemic preconditioning.
ISSN:1997-7298
DOI:10.17116/jnevro20181187154