Korean Red Ginseng Extract inhibits Tumor Necrosis Factor-alpha-induced Monocyte Adhesion in the Human Endothelial Cells

Vascular inflammation is an important step in the development of cardiovascular disorder. Since it has not been known whether Korean red ginseng has a role to play on the vascular inflammation, we investigated the effects of Korean red ginseng extract (KRGE) on monocyte adhesion and its underlying s...

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Published inJournal of ginseng research Vol. 32; no. 3; pp. 244 - 249
Main Authors Hee Kyoung Joo, Sang Ki Lee, Hyo Shin Kim, Yun Jeong Song, Gun Kang, Jin Bong Park, Kwon Ho Lee, Eun Jung Cho, Jae-Hwan Lee, In-Whan Seong, Se Hoon Kim, Chung-Hyun Cho, Byeong Hwa Jeon
Format Journal Article
LanguageEnglish
Published 고려인삼학회 30.09.2008
Subjects
기타의약학
superoxide production
Korean red ginseng extract
monocyte adhesion
adhesion molecule
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Summary:Vascular inflammation is an important step in the development of cardiovascular disorder. Since it has not been known whether Korean red ginseng has a role to play on the vascular inflammation, we investigated the effects of Korean red ginseng extract (KRGE) on monocyte adhesion and its underlying signaling mechanism. Monocyte adhesion assay and Western blot were conducted on the human umbilical vein endothelial cells to study monocyte adhesion and the expression of adhesion molecules. Intracellular calcium was measured with Fura-2 fluorescent staining, and superoxide production was measured with lucigenin chemiluminescence in the endothelial cells. KRGE inhibits tumor necrosis factor (TNF)-alpha-induced monocyte adhesion on the endothelial cells at the range of 0.03~1 mg/ml. TNF-alpha-induced vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1 expression were inhibited by the pretreatment of KRGE in the endothelial cells. KRGE also inhibits TNF-alpha-induced intracellular calcium and the superoxide production in the endothelial cells. This study first demonstrated that KRGE inhibits TNF-alpha-induced monocyte adhesion by inhibiting the adhesion molecule expression, intracellular calcium and superoxide production in the endothelial cells. Therefore, the anti-inflammatory function of KRGE may be contributed to protecting the endothelial dysfunction in the vascular inflammatory disorders. KCI Citation Count: 3
Bibliography:G704-000677.2008.32.3.010
ISSN:1226-8453
2093-4947
DOI:10.5142/jgr.2008.32.3.244