Synthesis of sulfur-containing glycerophospholipids

The inclusion of one or more sulfur atoms at the backbone of glycerophospholipids or phosphonolipids has created a number of new non-natural substrates for investigation in medicinal chemistry and enzymology. This review, containing 138 references, summarizes research contributions to date, with an...

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Bibliographic Details
Published inJournal of sulfur chemistry Vol. 28; no. 1; pp. 45 - 72
Main Authors Davy, Jason A., Wang, Zhongyi, Notter, Robert H., Schwan, Adrian L.
Format Journal Article
LanguageEnglish
Published Taylor & Francis 01.02.2007
Subjects
Biological activity
Lipases
Lipid analogs
Phospholipids
Phosphonolipids
Sulfur
Synthesis
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Summary:The inclusion of one or more sulfur atoms at the backbone of glycerophospholipids or phosphonolipids has created a number of new non-natural substrates for investigation in medicinal chemistry and enzymology. This review, containing 138 references, summarizes research contributions to date, with an emphasis on the synthetic organic chemistry that provides the lipids.
ISSN:1741-5993
1741-6000
DOI:10.1080/17415990601080166