RIPK1 and RIPK3 form mosaic necrosomes

Necrosomes formed by RIPK1–RIPK3 mediate necroptosis. Super-resolution microscopy identifies the architectural features of necrosomes and provides mechanistic insights into the signalling from RIPK1 to RIPK3 when RIPK1 is activated to mediate necroptosis, and from RIPK3 to RIPK1 when RIPK3 is inhibi...

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Bibliographic Details
Published inNature cell biology Vol. 24; no. 4; pp. 406 - 407
Main Authors Qi, Weiwei, Yuan, Junying
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.04.2022
Subjects
Apoptosis
Biology
Kinases
Microscopy
Mutation
Necroptosis
Phosphorylation
Proteins
Signal transduction
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Summary:Necrosomes formed by RIPK1–RIPK3 mediate necroptosis. Super-resolution microscopy identifies the architectural features of necrosomes and provides mechanistic insights into the signalling from RIPK1 to RIPK3 when RIPK1 is activated to mediate necroptosis, and from RIPK3 to RIPK1 when RIPK3 is inhibited to mediate apoptosis.
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ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-022-00879-y