Water-soluble core/shell nanoparticles for proton therapy through particle-induced radiation

• Published in: Journal of the Korean Physical Society Vol. 66; no. 3; pp. 486 - 490
• Main Authors: Park, Jeong Chan, Jung, Myung-Hwan, Kim, Maeng Jun, Kim, Kye-Ryung
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Physical Society 01.02.2015; 한국물리학회
• Subjects: Mathematical and Computational Physics; Particle and Nuclear Physics; Physics; Physics and Astronomy; Theoretical; 물리학; Phase transfer; Proton therapy; Core/shell nanoparticles
• ISSN: 0374-4884; 1976-8524
• DOI: 10.3938/jkps.66.486

Metallic nanoparticles have been used in biomedical applications such as magnetic resonance imaging (MRI), therapy, and drug delivery systems. Metallic nanoparticles as therapeutic tools have been demonstrated using radio-frequency magnetic fields or near-infrared light. Recently, therapeutic applications of metallic nanomaterials combined with proton beams have been reported. Particle-induced radiation from metallic nanoparticles, which can enhance the therapeutic effects of proton therapy, was released when the nanoparticles were bombarded by a high-energy proton beam. Core/shell nanoparticles, especially Au-coated magnetic nanoparticles, have drawn attention in biological applications due to their attractive characteristics. However, studies on the phase transfer of organic-ligand-based core/shell nanoparticles into water are limited. Herein, we demonstrated that hydrophobic core/shell structured nanomaterials could be successfully dispersed in water through chloroform/surfactant mixtures. The effects of the core/shell nanomaterials and the proton irradiation on Escherichia coli (E. coli) were also explored.