Emergence and properties of adult mammalian epidermal stem cells

In this review we discuss how the mammalian interfollicular epidermis forms during development, maintains homeostasis, and is repaired following wounding. Recent studies have provided new insights into the relationship between the stem cell compartment and the differentiating cell layers; the abilit...

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Published inDevelopmental biology Vol. 515; pp. 129 - 138
Main Authors Gadre, Purna, Markova, Pavlina, Ebrahimkutty, Mirsana, Jiang, Yidan, Bouzada, Francisco M., Watt, Fiona M.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.11.2024
Subjects
dedifferentiation
differentiation
epidermis
epigenetic memory
stem cell
wound healing
dedifferentiation
wound healing
differentiation
stem cell
epigenetic memory
epidermis
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Summary:In this review we discuss how the mammalian interfollicular epidermis forms during development, maintains homeostasis, and is repaired following wounding. Recent studies have provided new insights into the relationship between the stem cell compartment and the differentiating cell layers; the ability of differentiated cells to dedifferentiate into stem cells; and the epigenetic memory of epidermal cells following wounding. [Display omitted] •Switch between planar and perpendicular cell divisions during development.•Epidermal signalling is integrated at the cellular and supracellular levels.•Epigenetic environmental and lineage memory of wounding.
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ISSN:0012-1606
1095-564X
1095-564X
DOI:10.1016/j.ydbio.2024.07.014