Recurrent Episodes of Hypokalaemia during Treatment with Inhaled Beta-2 Agonist Revealing Gitelman Syndrome, an Uncommon Clinical Entity

A 28-year-old female patient was hospitalized for mild–moderate hypokalaemia which was persistent despite discontinuation of beta-2 agonist bronchodilator treatment. Her past medical history was relevant for two episodes of severe hypokalaemia after active inhaled beta-2 agonist treatment for asthma...

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Published inEuropean journal of case reports in internal medicine Vol. 9; no. 10; p. 003605
Main Authors Sablón-González, Nery, Parodis-Lopez, Yanet, Alonso-Ortiz, Maria Belen, Laurin, Angélica, Andres, Emmanuel, Lorenzo Villalba, Noel
Format Journal Article
LanguageEnglish
Published SMC Media Srl 20.10.2022
SMC MEDIA SRL
Subjects
gitelman syndrome
hypokalemia
metabolic alcalosis
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Summary:A 28-year-old female patient was hospitalized for mild–moderate hypokalaemia which was persistent despite discontinuation of beta-2 agonist bronchodilator treatment. Her past medical history was relevant for two episodes of severe hypokalaemia after active inhaled beta-2 agonist treatment for asthma crisis. Investigations revealed increased potassium in spot urine with a transtubular potassium gradient <4. A 24-hour urine analysis showed hypophosphaturia, hypocalciuria, hypomagnesuria and normal urine prostaglandins in favour of Gitelman syndrome. Oral potassium supplementation was started and genetic studies were recommended.
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ISSN:2284-2594
2284-2594
DOI:10.12890/2022_003605