Global motor dynamics - Invariant neural representations of motor behavior in distributed brain-wide recordings

• Published in: Journal of neural engineering Vol. 21; no. 5; pp. 56034 - 56045
• Main Authors: Ottenhoff, Maarten C, Verwoert, Maxime, Goulis, Sophocles, Wagner, Louis, van Dijk, Johannes P, Kubben, Pieter L, Herff, Christian
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.10.2024
• Subjects: brain–computer interface; motor decoding; neural dynamics; sEEG; neural dynamics; sEEG; motor decoding; brain-computer interface
• ISSN: 1741-2560; 1741-2552; 1741-2552
• DOI: 10.1088/1741-2552/ad851c

Motor-related neural activity is more widespread than previously thought, as pervasive brain-wide neural correlates of motor behavior have been reported in various animal species. Brain-wide movement-related neural activity have been observed in individual brain areas in humans as well, but it is unknown to what extent global patterns exist. Here, we use a decoding approach to capture and characterize brain-wide neural correlates of movement. We recorded invasive electrophysiological data from stereotactic electroencephalographic electrodes implanted in eight epilepsy patients who performed both an executed and imagined grasping task. Combined, these electrodes cover the whole brain, including deeper structures such as the hippocampus, insula and basal ganglia. We extract a low-dimensional representation and classify movement from rest trials using a Riemannian decoder. We reveal global neural dynamics that are predictive across tasks and participants. Using an ablation analysis, we demonstrate that these dynamics remain remarkably stable under loss of information. Similarly, the dynamics remain stable across participants, as we were able to predict movement across participants using transfer learning. Our results show that decodable global motor-related neural dynamics exist within a low-dimensional space. The dynamics are predictive of movement, nearly brain-wide and present in all our participants. The results broaden the scope to brain-wide investigations, and may allow combining datasets of multiple participants with varying electrode locations or calibrationless neural decoder.