Adenosine triphosphate infusion increases liver energy status in advanced lung cancer patients: An in vivo 31P magnetic resonance spectroscopy study

• Published in: Hepatology (Baltimore, Md.) Vol. 35; no. 2; pp. 421 - 424
• Main Authors: Leij‐Halfwerk, Susanne, Agteresch, Hendrik J., Sijens, Paul E., Dagnelie, Pieter C.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA W.B. Saunders 01.02.2002; Wiley
• Subjects: Adenosine Triphosphate - administration & dosage; Adenosine Triphosphate - therapeutic use; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; Energy Metabolism - drug effects; Female; Humans; Infusions, Intravenous; Intensive care medicine; Liver - metabolism; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Magnetic Resonance Spectroscopy; Male; Medical sciences; Middle Aged; Phosphorus; Reference Values; Severity of Illness Index; Weight Loss; Human; Lung disease; Respiratory disease; Liver; Weight loss; Hepatic disease; Metabolic diseases; Malignant tumor; Energetic state; Bronchopulmonary; Treatment; Perfusion; Digestive diseases; Bronchus disease; Complication; Catabolism; ATP; Non small cell carcinoma
• ISSN: 0270-9139; 1527-3350
• DOI: 10.1053/jhep.2002.31318

We recently observed inhibition of weight loss in patients with advanced nonsmall‐cell lung cancer after intravenous infusion of ATP. Because liver ATP levels were found to be decreased in lung cancer patients with weight loss, the present 31P magnetic resonance spectroscopy (MRS) study was aimed at investigating whether ATP infusion restores liver energy status in these patients. Nine patients with advanced nonsmall‐cell lung cancer (stage IIIB/IV) were studied 1 week before (baseline) and at 22 to 24 hours of continuous ATP infusion (37‐75 μg/kg/min). Localized hepatic 31P MR spectra (repetition time 15 seconds), obtained in the overnight‐fasted state, were analyzed for ATP and Pi content. Ten healthy subjects (without ATP infusion) served as control. Liver ATP levels in lung cancer patients increased from 8.8 ± 0.7% (relative to total MR‐detectable phosphate; mean ± SE) at baseline to 12.2 ± 0.9% during ATP infusion (P < .05), i.e., a level similar to that in healthy subjects (11.9 ± .9%). The increase in ATP level during ATP infusion was most prominent in patients with ≥5% weight loss (baseline: 7.9 ± 0.7%, during ATP infusion: 12.8 ± 1.0%, P < .01). In conclusion, ATP infusion restores hepatic energy levels in patients with advanced lung cancer, especially in weight‐losing patients. These changes may contribute to the previously reported beneficial effects of ATP infusion on the nutritional status of lung cancer patients.