Thyroid carcinoma in children and adolescents: a retrospective review

• Published in: Endocrinologia y nutricion Vol. 59; no. 2; p. 105
• Main Authors: Neiva, Filipa, Mesquita, Joana, Paco Lima, Susana, Matos, Maria João, Costa, Carla, Castro-Correia, Cintia, Fontoura, Manuel, Martins, Sofia
• Format: Journal Article
• Language: English
• Published: Spain 01.02.2012
• Subjects: Adolescent; Child; Female; Humans; Male; Retrospective Studies; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - surgery
• ISSN: 1579-2021
• DOI: 10.1016/j.endonu.2011.11.003

To describe clinical presentation, preoperative study, intervention, histology, surgical complications and follow-up characteristics, and survival in patients with thyroid carcinoma (TC) with less than 18 years at presentation. retrospective analysis of clinical data of all children and adolescents followed in S. João Hospital from January 1, 2000 to March 31, 2010 with histologic diagnosis of TC. Twenty-three patients were identified, 19 girls, and 4 boys. Median age at presentation was 17.0 years. Annual incidence was 2.3 cases/year. The main presenting symptom was a solitary thyroid nodule (60.8%). Three (13%) patients had risk factors for TC, 2 of the 3 had previous cervical irradiation. The other was a smoker. Total thyroidectomy was performed in 16 (69.6%), and 10 patients underwent a second surgical procedure. Four (17.4%) patients had postoperative complications. Histologic examination revealed differentiated TC in all, papillary thyroid carcinoma (PTC) in 86.9%, follicular carcinoma in the remaining. All patients received thyroxine suppressive therapy and 20 underwent therapeutic radioactive iodine (131I). During follow-up (7.1 years), 7 out of the 23 patients presented new metastases and needed new treatment. All patients are currently alive. TC is a reality in pediatric population, thyroid routine examination should take part in all clinical examination in children and adolescents.