The Diagnostic Value of β-Human Chorionic Gonadotropin, Progesterone, and Ischemia-Modified Albumin and Their Combined Use in the Prediction of First Trimester Abortions

• Published in: International scholarly research notices Vol. 2014; pp. 846531 - 5
• Main Authors: Osmanağaoğlu, Mehmet A., Karahan, S. Caner, Aran, Turhan, Güven, Süleyman, Turgut, Elif, Menteşe, Ahmet, Bozkaya, Hasan
• Format: Journal Article
• Language: English
• Published: United States Hindawi Publishing Corporation 01.07.2014
• ISSN: 2356-7872; 2356-7872
• DOI: 10.1155/2014/846531

Objective. To investigate serum levels of free β-HCG, progesterone, and ischemia-modified albumin (IMA) and their combined use in the prediction of first trimester abortions. Methods. A total of 156 pregnant women between 5 and 13 weeks of gestational age were included in this study. At admission, serum levels of free β-HCG, progesterone, and IMA were noted and all cases were divided into two groups; Group I ( n = 77 ) resulted in abortion including missed abortion, incomplete/complete abortion, and inevitable abortion whereas Group II ( n = 79 ) included normal pregnancies. Results. Compared to Group II, the significantly decreased value of free β-HCG progesterone and significantly increased value of IMA were found in Group I ( P < 0.01 , P < 0.01 , P < 0.01 , resp.). When combining all three parameters, sensitivity 75%, specificity 99%, PPV 98%, and NPV 76% were obtained. The multivariate logistic regression analysis revealed the free β-HCG, progesterone, and IMA independent factors in the prediction of abortions. Conclusions. The combined use of free β-HCG, progesterone, and IMA levels can be useful in the prediction of first trimester spontaneous abortions.