Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21

People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer�...

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Bibliographic Details
Published inProgress in brain research Vol. 251; pp. 181 - 208
Main Authors Cannavo, Claudia, Tosh, Justin, Fisher, Elizabeth M C, Wiseman, Frances K
Format Journal Article
LanguageEnglish
Published Netherlands 2020
Subjects
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Animals
Disease Models, Animal
Down Syndrome - drug therapy
Down Syndrome - genetics
Down Syndrome - metabolism
Down Syndrome - pathology
Mice
Mouse models
Alzheimer's disease
Down syndrome
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Summary:People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer's disease and generate new clinical research questions. In addition, they suggest potential new targets for disease prevention therapies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1875-7855
DOI:10.1016/bs.pbr.2019.10.004