Experience of Non-Hodgkin's Lymphoma in the Central Nervous System Presented as Neurological Deficit from 2017-2021 in a Medical Center in Mexico City

• Published in: Turkish neurosurgery Vol. 33; no. 3; pp. 488 - 493
• Main Authors: Orlando, Pérez-Campos, Paola, Gallego-Henao Katherine, Angélica, Moreno-Blanco, Andres, Jaime-Aguirre, Aureliano, Placido-Mendez, Lizbeth, Sandoval-Olivares
• Format: Journal Article
• Language: English
• Published: Turkey 01.01.2023
• Subjects: Central Nervous System; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Lymphoma, Non-Hodgkin; Mexico; Mexico
• ISSN: 1019-5149
• DOI: 10.5137/1019-5149.JTN.41850-22.3

To show the oddity of primary central nervous system lymphoma (PCNSL) and illustrate the histopathological and magnetic resonance imaging (MRI) characteristics of this disease entity. We obtained the histopathological diagnosis through stereotactic biopsy, and all lesions were resected at the Department of Neurosurgery, Centro Medico Nacional 20 de Noviembre. We identified and included six lymphoma cases in a 5-year period: none of the patients had human immunodeficiency virus (HIV) infection; none were Epstein-Barr virus (EVB)-positive; all of them received chemotherapy and radiotherapy; and the survival rate was ≥1 year. Regarding the clinical data, the symptoms entirely depended on the location of the lesions. If the symptoms suggest malignancy, such as fever, weight loss, and night sweats, we searched for causes, other than the usual ones, to find a diagnosis. This is a rare disease, which responds well to medical treatment and has a survival greater than 5 years in some cases.