Synthesis of 2'-O-methyl-5-alkynyl and alkenyl substituted uridine derivatives to screen for inhibitors of HCV

Using Sonogashira and Heck coupling reactions, a series of 5-alkynyl and 5-alkenyl substituted 2'-O-methyluridine derivatives were synthesized in high yields. These compounds were used to screen for inhibitors of HCV, however none of them showed significant HCV inhibitory activity under 300 mu...

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Bibliographic Details
Published inHeterocycles Vol. 68; no. 3; pp. 521 - 530
Main Authors Ding, VL, Girardet, JL, Hong, Z, Shaw, SZ, Yao, NH
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.03.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SELECTIVE-INHIBITION
POTENT
NUCLEOSIDE ANALOGS
VARICELLA-ZOSTER-VIRUS
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Summary:Using Sonogashira and Heck coupling reactions, a series of 5-alkynyl and 5-alkenyl substituted 2'-O-methyluridine derivatives were synthesized in high yields. These compounds were used to screen for inhibitors of HCV, however none of them showed significant HCV inhibitory activity under 300 mu M.
ISSN:0385-5414
DOI:10.3987/COM-05-10639