Platelet function disorder in Gardner-Diamond syndrome: a case report and review of the literature

The Gardner-Diamond syndrome is a disorder characterized by recurrent spontaneous painful bruising in patients with underlying psychosis and neurosis. Despite the presence of other symptoms suggestive of an underlying disorder of primary hemostasis in a large percentage of reported patients, results...

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Bibliographic Details
Published inJournal of pediatric hematology/oncology Vol. 27; no. 6; p. 323
Main Authors Puetz, John, Fete, Timothy
Format Journal Article
LanguageEnglish
Published United States 01.06.2005
Subjects
Adenosine Diphosphate - pharmacology
Adolescent
Arachidonic Acid - pharmacology
Blood Coagulation Disorders - blood
Blood Platelet Disorders - blood
Contusions
Female
Gardner Syndrome - blood
Humans
Mental Disorders
Platelet Aggregation - drug effects
Psychotic Disorders
Syndrome
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Summary:The Gardner-Diamond syndrome is a disorder characterized by recurrent spontaneous painful bruising in patients with underlying psychosis and neurosis. Despite the presence of other symptoms suggestive of an underlying disorder of primary hemostasis in a large percentage of reported patients, results of testing for von Willebrand disease or platelet function disorders are lacking. The authors describe a case of Gardner-Diamond syndrome in an adolescent girl who had abnormal platelet responses during platelet aggregation studies. A review of the literature revealed only three additional patients with Gardner-Diamond syndrome who have had platelet aggregation studies reported. To date, all patients with Gardner-Diamond syndrome reported to have undergone platelet aggregation studies have had abnormal results.
ISSN:1077-4114
DOI:10.1097/01.mph.0000168726.64766.c6