SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF UNSATURATED PYRIMIDINE CARBOACYCLONUCLEOSIDE ANALOGUES

The novel pyrimidine carboacyclonucleoside analogues containing propargylated aryl side chains were synthesized via palladium-catalyzed cross-coupling reactions as a key step. The synthesized compounds were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus...

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Bibliographic Details
Published inCollection of Czechoslovak chemical communications Vol. 76; no. 11; pp. 1299 - 1305
Main Authors Krim, Jamal, Sillahi, Bouchra, Taourirte, Moha, Eddarir, Said, Engels, Joachim W.
Format Journal Article
LanguageEnglish
Published PRAGUE 6 Inst Organic Chem And Biochem 01.01.2011
Blackwell Publishing Ltd
Subjects
Antimicrobial agents
Bacteria
Chemistry
Chemistry, Multidisciplinary
E coli
Microbiology
Microorganisms
Physical Sciences
Science & Technology
N-Alkylation
NUCLEOSIDES
Thymine
Palladium
DRUG-RESISTANCE
ACYCLONUCLEOSIDES
Alkylation
Nucleobases
Antibiotics
Antibacterial activity
ANTIMICROBIAL ACTIVITY
Sonogashira cross-coupling
Alkynes
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Summary:The novel pyrimidine carboacyclonucleoside analogues containing propargylated aryl side chains were synthesized via palladium-catalyzed cross-coupling reactions as a key step. The synthesized compounds were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (CIP 53.154; Gram positive), Enterococcus hirae (CIP 58.55; Gram positive), Pseudomonas aeruginosa (CIP A22; Gram negative), Escherichia coli (CIP 54.8; Gram negative). Some of the prepared products showed promising antibacterial activity against the nosocomial E. hirae.
ISSN:0010-0765
1212-6950
1212-6950
2192-6506
DOI:10.1135/cccc2011083