Treatment of chronic infection

Failure of an acute inflammatory response to resolve a wound infection heralds a cascade of events that affects the host and pathogens, culminating in a chronic, refractory condition. The factors contributing to this outcome include immune compromise of the host, antimicrobial resistance, wound-heal...

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Bibliographic Details
Published inJournal of the American Academy of Orthopaedic Surgeons Vol. 14; no. 10 Spec No.; p. S105
Main Authors Cierny, 3rd, George, DiPasquale, Doreen
Format Journal Article
LanguageEnglish
Published United States 2006
Subjects
Anti-Bacterial Agents - therapeutic use
Chronic Disease
Debridement - methods
Humans
Treatment Outcome
Warfare
Wound Infection - drug therapy
Wounds, Penetrating - surgery
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Summary:Failure of an acute inflammatory response to resolve a wound infection heralds a cascade of events that affects the host and pathogens, culminating in a chronic, refractory condition. The factors contributing to this outcome include immune compromise of the host, antimicrobial resistance, wound-healing deficiencies, and the adherence of pathogens to themselves and wound surfaces via an impenetrable, resistant biofilm. To eradicate chronic infection, the pathogens, biofilm, surfaces available for adherence, and compromised tissue must be removed.
ISSN:1067-151X
DOI:10.5435/00124635-200600001-00025