Mouse- and patient-derived CAM xenografts for studying metastatic renal cell carcinoma

Renal cell carcinoma is the seventh most common cancer in the United States, and its metastatic form has a very poor prognosis due to a lack of effective treatment and thorough understanding on metastatic mechanism. This chapter will demonstrate a novel concept that intratumoral heterogeneity is ess...

Full description

Saved in:
Bibliographic Details
Published inThe Enzymes Vol. 46; p. 59
Main Authors Ishihara, Moe, Hu, Junhui, Wong, Anthony, Cano-Ruiz, Celine, Wu, Lily
Format Journal Article
LanguageEnglish
Published United States 2019
Subjects
Animals
Carcinoma, Renal Cell - pathology
Chick Embryo
Chorioallantoic Membrane - pathology
Disease Models, Animal
Humans
Kidney Neoplasms - pathology
Mice
Neoplasm Metastasis
Neoplasm Transplantation
Prognosis
Animal model
CRISPR/Cas9 gene editing
Renal cell carcinoma
Renal implantation
VHL gene deletion
Metastasis
Intratumoral heterogeneity
Online AccessGet more information

Cover

More Information
Summary:Renal cell carcinoma is the seventh most common cancer in the United States, and its metastatic form has a very poor prognosis due to a lack of effective treatment and thorough understanding on metastatic mechanism. This chapter will demonstrate a novel concept that intratumoral heterogeneity is essential for metastasis in renal cell carcinoma. We will first introduce the in vitro system and the mouse model that led to the finding of the cooperative mechanism for metastasis. Then, the results from the CAM model illustrate the cooperative interactions that lead to metastasis also occur in this model. We believe that the CAM model, as a unique and sustainable system, can open up new opportunities to study the metastatic disease.
ISSN:0423-2607
DOI:10.1016/bs.enz.2019.08.009