Immunophenotype and Ultrastructure of B-cell Lymphoproliferative Disorder with Cytoplasmic Projection

• Published in: Current medical science Vol. 23; no. 3; pp. 236 - 238
• Main Author: 刘新月 胡闲石 樊丽华 阮幼冰
• Format: Journal Article
• Language: English
• Published: China Institute of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhah 430022%Ultrastructure Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 2003
• Subjects: Adolescent; Adult; Aged; Antibodies, Neoplasm - blood; Antigens, Differentiation, B-Lymphocyte - blood; Antigens, Neoplasm - blood; B-Lymphocytes - immunology; B-Lymphocytes - ultrastructure; Bone Marrow Cells - pathology; B细胞; Cytoplasm - ultrastructure; Female; Humans; Immunophenotyping; Leukemia, Hairy Cell - immunology; Leukemia, Hairy Cell - pathology; Lymphoma, B-Cell - immunology; Lymphoma, B-Cell - ultrastructure; Lymphoproliferative Disorders - immunology; Lymphoproliferative Disorders - pathology; Male; Middle Aged; 免疫显型; 淋巴组织增生; 细胞质投射; 超微结构; electron microscopy; lymphoproliferative disorder; hairy cell; immunophenotyping
• ISSN: 1672-0733; 2096-5230; 2523-899X
• DOI: 10.1007/bf02829501

To identify the knowledge of rare lymphoproliferative disorder, the clinical and biological features of three kinds of lymphoproliferative disorders with cytoplasmic projections were compared. The clinical manifestations, ultrastructure and immunophenotype were analyzed. The results showed that hairy cell leukemia (HCL), splenic lymphoma with villous lymphocyte (SLVL) and hairy cell leukemia-variant (HCL-V) had some common characters including splenomegaly, peripheral blood and bone marrow infiltration by villous lymphocyte and B lymphocyte immunophenotype；but these three disorders had specific features respectively. It was concluded that overall analysis of clinical and laboratory features might be contributive to the differential diagnosis of these three disorders.